Biopharma Provenance
✓ 100% Deterministic Python Engine (v1.1.0) Snowflake Marketplace Native App AWS Data Exchange Databricks Unity Catalog ALCOA+ & EU AI Act Art. 10/13 Ready

Cross-Ontology Biopharma, Clinical Trial Arbitrage & FDA Safety On-Demand Engine

Unifying human genetic constraint (gnomAD v4 / Open Targets), 3D structural druggability (RCSB PDB / UniProtKB), nanomolar kinome selectivity (ChEMBL), terminated trial rescue signals (ClinicalTrials.gov), and post-market disproportionality (openFDA FAERS)—verified with dual-origin HTTP 200 OK provenance and SHA-256 cryptographic lineage.

Interactive On-Demand Target Intelligence Engine (Live Sample)

Test the exact interface deployed inside the buyer's personal Snowflake container. Type or click any benchmark target below to inspect its deterministic conviction breakdown and relational tables.

Sample Targets:
Composite Conviction
90.97 / 100
Deterministic Score
Human Genetics (40)
36.36
Open Targets + LOF
Selectivity Window (30)
30.00
ChEMBL vs Antitarget
Haplosufficiency (15)
12.61
gnomAD v4 LOEUF CI
FDA FAERS Safety (15)
12.00
openFDA RRR Signal

6-Table Relational Schema & Data Dictionary

All tables join cleanly on ENSEMBL_GENE_ID (`ENSG...`) and TARGET_CHEMBL_ID (`CHEMBL...`), with dual-origin web portal and raw JSON API URLs locked in every row.

1. DIM_TARGETS_GENETICS

Human Genetics & gnomAD Constraint

Canonical ENSEMBL_GENE_ID, UNIPROT_ACCESSION, PRIMARY_PDB_ID, gnomAD v4 LOEUF 90% confidence intervals, protective coding variants (dbSNP), and deterministic conviction scores.

2. FACT_BIOACTIVITY_SELECTIVITY

Quantitative Kinome & Antitarget Selectivity

Verified nanomolar Ki / IC50 / Kd assays from ChEMBL comparing primary on-target potency against off-target paralogs (e.g., JAK1/2/3) and cardiac safety antitargets (KCNH2 / hERG).

3. FACT_CLINICAL_TRIALS_ARBITRAGE

Terminated Trial Deconvolution

Cross-references TERMINATED / WITHDRAWN trials from ClinicalTrials.gov APIv2 against human genetic evidence to separate ASSET_PK_FAILURE_TARGET_INTACT rescue opportunities from mechanism failures.

4. FACT_FDA_SAFETY_SIGNALS

openFDA FAERS Post-Market Baselines

Adverse event reporting proportions and Relative Reporting Ratios (RRR) across MedDRA preferred terms comparing selective allosteric modulators against non-selective orthosteric comparators.

5. FACT_ALPHAGENOME_NONCODING_VARIANTS

Non-Coding Regulatory & Splice Impact (Tier 3)

Pre-computed AlphaGenome Variant Impact (AVI Phred) predictions for intronic splice enhancers, promoters, and distal cCREs with direct AlphaGenome Atlas deep-links (Research Use Only).

6. FACT_3D_STRUCTURAL_OFFTARGETS

3D Structural Pocket Twins (Tier 3)

Proteome-wide 3D binding-pocket similarity matches (Foldseek / AlphaFold DB) identifying cryptic structural off-targets invisible to 1D sequence BLAST searches.

Deterministic Bio-Linter & EU AI Act / ALCOA+ Provenance

Zero LLM hallucination risk: every score and classification is computed by deterministic Python rules verified by 6 automated biological domain invariants.

Dual-Origin HTTP-200 Provenance

Every row embeds both the clickable Human Web Portal URL and the exact Machine REST/GraphQL API endpoint URL so investment committees and auditors can verify raw values in one click.

Cryptographic SHA-256 Lineage

Every target bundle and multi-target batch manifest is signed with a canonical SHA-256 Merkle digest, satisfying FDA ALCOA+ data integrity and EU AI Act Articles 10 & 13 traceability requirements.

In-Container Privacy Execution

When deployed via Snowflake Native App, target searches execute directly inside the subscriber's personal Snowflake environment—ensuring confidential pipeline queries are never exposed.

Transparent Institutional Marketplace Pricing (USD)

Available via 1-click subscription on Snowflake Marketplace, AWS Data Exchange, and Databricks Marketplace. All paid tiers include unlimited on-demand target searches with zero per-query fees.

Tier 1 • Evaluation

Free Trial Sample

$0 / month
Instant read-only evaluation
  • ✓ 5 Benchmark Targets Included: TYK2, PCSK9, GLP1R, SCN10A, IL23R
  • ✓ Full access to VW_FREE_SAMPLE_5_TARGETS
  • ✓ Interactive Streamlit UI preview inside Snowflake
  • ✓ 100% live HTTP 200 OK provenance URLs & SHA-256 hashes
Tier 2 • Most Popular

Core Provenance & Arbitrage Baseline

$4,500 / month
or $48,000 / year (Saves $6,000)
  • ✓ Unlimited On-Demand Target Searches (Any human gene symbol or ENSG... ID)
  • ✓ All 4 Core Relational Tables (DIM_TARGETS_GENETICS, FACT_BIOACTIVITY_SELECTIVITY, FACT_CLINICAL_TRIALS_ARBITRAGE, FACT_FDA_SAFETY_SIGNALS)
  • ✓ Secure View: VW_RESCUABLE_TERMINATED_TRIALS
  • ✓ 1-Click Executive Markdown Dossier & Signed JSON Exports
Tier 3 • Institutional Suite

In-Silico Superpower Suite

$9,500 / month
or $98,000 / year (Saves $16,000)
  • ✓ Unlimited On-Demand Target Searches across all 6 tables
  • ✓ Everything in Tier 2 Core Baseline
  • ✓ Plus: FACT_ALPHAGENOME_NONCODING_VARIANTS (AVI Phred regulatory/splice scores)
  • ✓ Plus: FACT_3D_STRUCTURAL_OFFTARGETS (Foldseek / AlphaFold 3D pocket twins) & VW_INSTITUTIONAL_360_RISK_MATRIX